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Could theoretical concerns about receptor downregulation, disrupting natural growth factor signaling, or other homeostasis disturbances exist

Am J Physiol 263: C1181C1189

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Acetaldehyde further compromises the ER by modifying chaperones and enzymes, interfering with disulfide bond formation and glycosylation, depleting glutathione, disturbing calcium signaling, and causing homocysteine accumulation ( Alcohol and endogenous aldehydes also cause DNA double-strand breaks and chromosomal rearrangements in hematopoietic stem cells

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